The Giorgi Lab is located within the Department of Pharmacy and Biotechnology at the University of Bologna, Italy.
We aim to understand how Gene Networks work, in terms of transcriptional regulation and signal transduction.
Our analysis allowed us to define the effects of the human/SARS-CoV-2 protein-protein interactions on the transcriptome of bronchial human cells (ref: Journal of Clinical Medicine https://www.mdpi.com/2077-0383/9/4/982). In the following figure, viral proteins are green circles, human proteins are squares:
Transcriptional networks are often exploited and rewired by cancer cells during the process of tumorigenesis.
We use a computational approach with experimental validation. One of our approaches focuses on single cell RNA-Seq as a tool to investigate sample heterogeneity and network rearrangements during transient gene silencing and cell cycle phases:
We teach applied Bioinformatics in the Genomics BSc course: http://tiny.cc/genomunibo
We are looking for a motivated PostDoc!
Bioinformatics is PoetryStannis Baratheon, PhD